Pal-AHK (Palmitoyl Tripeptide-3) 200mg – Research Grade

Look, here’s the deal on Pal-AHK. This isn’t magic dust. It’s a purpose-built research peptide, a modified tripeptide (Alanine-Histidine-Lysine) with a palmitoyl fatty acid attached. That fatty acid tail isn’t for show. In experimental models, it makes the peptide lipophilic—fat-soluble. This is theorized to enhance penetration and absorption into epidermal cell layers for targeted in vitro study. Think of it as the difference between standard and penetrating oil.

The core mechanism is tied to copper. Pal-AHK is a potent copper-binding peptide. The research, which we’ll get to, suggests this copper complex (AHK-Cu) plays a significant role in cellular functions related to the extracellular matrix (ECM).

What The Research Indicates

We deal in facts, not fairy tales. Here’s what the published studies suggest for laboratory investigation:

• Fibroblast Proliferation & Collagen: Key in vitro studies show that AHK-Cu may support the proliferation and viability of dermal fibroblasts. These are the cells responsible for building the ECM. One assay method (sulforhodamine B staining) indicated increased cell growth. More importantly, research using sandwich ELISA assays reported that fibroblasts exposed to AHK-Cu produced up to 300% more collagen type I than control cells. The proposed mechanism involves stimulating the biosynthetic pathways for collagen production.
• Antioxidant & Structural Activity: Chromatographic evaluations suggest Pal-AHK possesses significant antioxidative potential, linked to its metal-chelating properties. It’s also posited to interact with cellular processes, potentially supporting the expression of growth factors and activating enzymes (MMPs) involved in ECM remodeling—clearing out old proteins to make way for new ones.
• Angiogenesis & Hair Follicle Studies: Molecular docking studies in silico show the tripeptide binds to VEGFR2, a key protein in angiogenesis (new blood vessel formation), suggesting a pathway for further experimental research. Separate lab studies on dermal papilla cells (crucial for hair follicle growth) indicate AHK-Cu may stimulate cell proliferation and inhibit apoptosis (programmed cell death). It’s shown to potentially elevate the Bcl-2/Bax protein ratio and decrease markers like cleaved caspase-3, while also modulating growth factors like VEGF and TGF-β1.

Specifications

Molecular Formula:	C31H56N6O5
Molecular Weight:	592.80 g/mol
Sequence:	Palmitoyl-Ala-His-Lys
Synonyms:	Palmitoyl Tripeptide-3
Purity:	≥98% (HPLC verified)
Quantity:	200mg in sterile glass vial