Pentapeptide-18 (Leuphasyl) – 200mg

$236.50

All orders placed before 12 PM PST ship same day. This material is for laboratory research use only by qualified professionals. Not for human or animal consumption.

You’re looking at Pentapeptide-18, also known as Leuphasyl. Think of it as a precision tool for cellular research, specifically in the study of skin aging mechanisms. This isn’t a vague “maybe” compound; it’s a synthetically modified version of a natural enkephalin peptide, engineered with D-Alanine for stability and skin penetration.

Here’s the straightforward breakdown of its research value:

Primary Research Focus: Muscle Contraction & Wrinkle Formation

Leuphasyl is studied for its potential to influence the signals that cause muscle fibers to contract. The proposed mechanism is a modulation of calcium release and acetylcholine secretion at the synaptic level. In simpler terms, it may help calm down the repetitive firing that leads to expression lines. Published data is compelling. One clinical study noted wrinkle reduction averages of 34.7% in the forehead and 28.4% in the eye area after application. Another study by Dr. Howard Maibach at UC San Francisco reported a standalone 11% reduction in wrinkles with a 5% Leuphasyl formulation over 28 days.

Synergistic Potential

The data gets more interesting in combination. Maibach’s same study found that combining 5% Leuphasyl with 5% Argireline (Acetyl Hexapeptide-8) pushed average wrinkle reduction to nearly 25%, with peaks around 47%. This makes it a key candidate for research into multi-peptide topical formulations aimed at mimicking more invasive procedures.

Secondary Research Pathway: Melanin Synthesis

Modified versions of this peptide, specifically with a D-tyrosine addition, have shown preliminary in vitro potential to influence melanogenesis in MNT-1 melanoma cells. This suggests a possible research avenue for hyperpigmentation studies, though this is a distinct derivative from the base Leuphasyl we offer.

Why Researchers Choose Our Batch

You get 200mg of pure, lyophilized powder. It’s third-party verified for sequence (Tyr-D-Ala-Gly-Phe-Leu) and purity. We ship it stable at room temperature. No filler, no guesswork. It’s a research-grade tool for serious in-vitro or ex-vivo experimentation on tissue models.

If your work involves dermatological science, neurocosmetic pathways, or