Description
Research-Grade Tesamorelin + CJC-1295 (Mod GRF 1-29) + Ipamorelin Tri-Blend (12mg)
Let’s cut to the chase. You’re here because you know what growth hormone secretagogues are and you’re looking for a serious, no-compromise blend for your research. This isn’t a starter kit. This is a precision-engineered stack combining three of the most targeted peptides for studying GH release pathways. We’re talking about a 12mg vial where each component is chosen for a specific job, working on different receptor types (GHRH and GHS) to provide a comprehensive research model. If you’re compiling data on somatotroph cell response, this blend is your core reagent.
What This Blend Is For
This tri-peptide blend is formulated for in-vitro laboratory research into the mechanisms of growth hormone synthesis and secretion. It combines Tesamorelin, CJC-1295 (Mod GRF 1-29), and Ipamorelin to simultaneously engage both Growth Hormone-Releasing Hormone (GHRH) receptors and Growth Hormone Secretagogue (GHS) receptors. The objective is to provide a research tool that can stimulate pituitary cell activity through multiple, synergistic signaling pathways for observational study.
Breakdown of Components: No Marketing, Just Specs
1. Tesamorelin: The Engineered GHRH Analog
Tesamorelin is a synthetic 44-amino acid peptide built on the GHRH sequence. Its design includes key modifications: an acetyl group at the N-terminus and a trans-3-hexenoic acid group at the C-terminus. In research settings, these modifications are significant because they are observed to enhance metabolic stability and resist enzymatic degradation, leading to a more prolonged interaction with GHRH receptors on pituitary somatotrophs. Published studies note its association with increased total GH output and significant increases in IGF-1 levels in research models.
- Molecular Formula: C221H366N72O67S
- Molecular Weight: 5136 g/mol
- Sequence: trans-hexenoyl-acid-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-AsnSer-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-LeuGln-Asp-Ile-Met-Ser-Arg-GlnGln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu
2. CJC-1295 (Mod GRF 1-29): The Precision Tool
Don’t confuse this with the DAC version. This is Mod GRF 1-29, the tetrasubstituted analog of the shortest functional GHRH fragment. Its four amino acid substitutions (D-Ala2, Lys8, D-Phe15, Sar27) serve one primary research purpose: to drastically increase stability and binding affinity to the GHRH receptor while extending half-life by resisting cleavage. Think of it as a direct, efficient key for the GHRH receptor lock. Research indicates it can produce a sustained increase in GH and IGF-1 levels in experimental models, making it valuable for studying prolonged secretory pulses.
- Molecular Formula: C152H252N44O42
- Molecular Weight: 3367.954 g/mol
- Sequence: YDADAIFTQSYRKVLAQLSARKL LQDILSR-NH2
3. Ipamorelin: The Selective GHS Agonist
Ipamorelin rounds out the blend by hitting the ghrelin (GHS) receptor pathway. Its value in research is its noted selectivity. Studies suggest it triggers GH release from somatotrophs without significant cross-activity that leads to cortisol or ACTH release in models. This allows for the isolation of the GH secretion pathway via this mechanism. It works through a different intracellular signaling cascade (PLC, IP3, DAG, PKC) than the GHRH analogs, providing a complementary route to stimulate GH vesicle exocytosis. Data shows it can provoke a significant spike in GH secretion levels in experimental comparisons.
- Molecular Formula: C38H49N9O5
- Molecular Weight: 711.868 g/mol
- Sequence: Aib-His-D-2Nal-D-Phe-Lys
Research Context & Observed Data Points
The following is a summary of findings from published third-party research on these peptides individually. This data is for educational context to inform your research objectives.
- GH & IGF-1 Output: Tesamorelin studies report a ~69% increase in total GH (AUC) and a ~122% rise in IGF-1. CJC-1295 (Mod GRF) research notes a 70-107% increase in GH release over 12 hours with a ~28% rise in IGF-1. Ipamorelin exposure has been associated with GH secretion levels approximately 60x higher than placebo in controlled models.
- Body Composition Metrics: In experimental models, Tesamorelin has been correlated with improved muscle tissue density and volume, and reduced intramuscular fat. A long-term study on a CJC-1295 analog noted increased skeletal muscle mass. Ipamorelin research suggests a potential to
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